Isabella Romola de' Medici (31 August 1542 – 16 July 1576) was the daughter of Cosimo I de' Medici, first Grand Duke of Tuscany, and Eleonora di Toledo.

She was born in Florence.In 1553, when she was only 11 years old, Isabella was bethroted to Paolo Giordano Orsini, a violent condottiero who held the Duchy of Bracciano, a southern neighbour to Tuscany. The two married in 1558.Isabella had allegedly an open character that created rumours about her behaviour, especially for the nature of her relationship with Troilo Orsini, Paolo Giordano's cousin who had allegedly the task to look after her during the Duke's absence for military duties.Paolo Giordano eventually was informed of her infidelity. Having died his powerful father, the duke had her strangled in the Villa di Cerreto Guidi, near Florence, probably with the complicity of the new Grand Duke, her brother Francesco. Troilo met the same end in Paris some months later.According to tradition, the unrest Isabella's ghost appears periodically in several places in which she inhabited.

Isabella Di Medici Birth Chart. (Born 08.31.1542) (Left)